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Joslin Diabetes Center

One Joslin Place

Room 4504B (Mezzanine)

Boston, MA 02215

phone: 617-309-4057




     

Research Summary

The Kostic lab strives to uncover and understand the immunomodulatory functions of the symbiotic microbiota and their impact on type 1 diabetes and related autoimmune diseases. Lab members are involved in one or more of the following 3 research themes:

(1) Computational analysis of large patient cohorts including genomic, transcriptomic, and metabolomic datasets of the host and gut microbiome to identify microbial products associated with disease or health.
(2) Engineering microbes via synthetic biology to enhance or disrupt these products.
(3) Mechanistic studies in humanized, gnotobiotic mouse models to understand how these microbial products impact disease.

Please visit the Kostic lab webpage:

http://kosticlab.org

Selected Publications

Vatanen T*, Kostic AD*, d'Hennezel E*, Siljander H, Franzosa EA, Yassour M, Kolde R, Vlamakis H, Arthur TD, Hämäläinen AM, Peet A, Tillmann V, Uibo R, Mokurov S, Dorshakova N, Ilonen J, Virtanen SM, Szabo SJ, Porter JA, Lähdesmäki H, Huttenhower C, Gevers D, Cullen TW, Knip M; DIABIMMUNE Study Group, Xavier RJ. Variation in Microbiome LPS Immunogenicity Contributes to Autoimmunity in Humans. Cell. 2016 May 5;165(4):842-53. doi: 10.1016/j.cell.2016.04.007. Epub 2016 Apr 28. PubMed PMID: 27133167; PubMed Central PMCID: PMC4950857.

Kostic AD, Gevers D, Siljander H, Vatanen T, Hyötyläinen T, Hämäläinen AM, Peet A, Tillmann V, Pöhö P, Mattila I, Lähdesmäki H, Franzosa EA, Vaarala O, de Goffau M, Harmsen H, Ilonen J, Virtanen SM, Clish CB, Orešic M, Huttenhower C, Knip M; DIABIMMUNE Study Group, Xavier RJ. The dynamics of the human infant gut microbiome in development and in progression toward type 1 diabetes. Cell Host & Microbe. 2015 Feb 11;17(2):260-73. doi: 10.1016/j.chom.2015.01.001. Epub 2015 Feb 5. PubMed PMID: 25662751; PubMed Central PMCID: PMC4689191.

Kostic AD, Chun E, Robertson L, Glickman JN, Gallini CA, Michaud M, Clancy TE, Chung DC, Lochhead P, Hold GL, El-Omar EM, Brenner D, Fuchs CS, Meyerson M, Garrett WS. Fusobacterium nucleatum potentiates intestinal tumorigenesis and modulates the tumor-immune microenvironment. Cell Host & Microbe. 2013 Aug 14;14(2):207-15. doi: 10.1016/j.chom.2013.07.007. PubMed PMID: 23954159; PubMed Central PMCID: PMC3772512.

Kostic AD, Gevers D, Pedamallu CS, Michaud M, Duke F, Earl AM, Ojesina AI, Jung J, Bass AJ, Tabernero J, Baselga J, Liu C, Shivdasani RA, Ogino S, Birren BW, Huttenhower C, Garrett WS, Meyerson M. Genomic analysis identifies association of Fusobacterium with colorectal carcinoma. Genome Research. 2012 Feb;22(2):292-8. doi: 10.1101/gr.126573.111. Epub 2011 Oct 18. PubMed PMID: 22009990; PubMed Central PMCID: PMC3266036.

Kostic AD, Ojesina AI, Pedamallu CS, Jung J, Verhaak RG, Getz G, Meyerson M. PathSeq: software to identify or discover microbes by deep sequencing of human tissue. Nature Biotechnology. 2011 May;29(5):393-6. doi: 10.1038/nbt.1868. PubMed PMID: 21552235; PubMed Central PMCID: PMC3523678.